Conservative Management of Delayed Submucosal Bleeding after Per-Oral Endoscopic Myotomy: A Case Report
Case studies
Martina Marrelli
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
https://orcid.org/0000-0002-6268-0502
Dario Biasutto
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
https://orcid.org/0000-0002-9372-8986
Benedetto Neri
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
https://orcid.org/0000-0002-0803-7903
Serena Stigliano
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
Nicolò Citterio
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
https://orcid.org/0009-0003-0438-9105
Monica Pandolfi
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
Gianluca Andrisani
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
Francesco Maria Di Matteo
Therapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, University of Rome, Rome, Italy
https://orcid.org/0000-0002-8528-1539
Published 2024-12-26
https://doi.org/10.15388/Amed.2024.31.2.15
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Keywords

POEM
hematoma
submucosal bleeding
delayed bleeding

How to Cite

1.
Marrelli M, Biasutto D, Neri B, Stigliano S, Citterio N, Pandolfi M, et al. Conservative Management of Delayed Submucosal Bleeding after Per-Oral Endoscopic Myotomy: A Case Report. AML [Internet]. 2024 Dec. 26 [cited 2025 Apr. 26];31(2):388–393. Available from: https://journals.vu.lt./AML/article/view/35946

Abstract

Per-Oral Endoscopic Myotomy (POEM) is recognized as the first-line therapy for achalasia, considering its high clinical efficacy and safety. Among the most important adverse events, bleeding or hematoma in the submucosal tunnel has incidence of approximately 1%.
We describe the case of woman affected by type II achalasia, treated with POEM, who presented delayed bleeding with submucosal hematoma after starting anticoagulant therapy with subcutaneous low molecular weight heparin (LMWH).
She presented with moderate-to-severe chest pain, stable vital signs and no evidence of arterial active bleeding. Therefore, urgent esophagogastroduodenoscopy was not performed, and the patient was treated conservatively with fasting, antibiotics, LMWH discontinuation and close medical supervision. After 10 days the condition was resolved, and the patients safely discharged.
The present case report adds support to the safety and efficacy of conservative management of submucosal hematomas occurring after POEM.

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